Cryo-EM structure of pre-liganded NAIP5 reveals activation mechanism of NAIP/NLRC4 inflammasome
نویسندگان
چکیده
منابع مشابه
Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.
The NLR family apoptosis inhibitory proteins (NAIPs) bind conserved bacterial ligands, such as the bacterial rod protein PrgJ, and recruit NLR family CARD-containing protein 4 (NLRC4) as the inflammasome adapter to activate innate immunity. We found that the PrgJ-NAIP2-NLRC4 inflammasome is assembled into multisubunit disk-like structures through a unidirectional adenosine triphosphatase polyme...
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Inflammasomes are cytosolic multiprotein complexes that assemble in response to infectious or noxious stimuli and activate the CASPASE-1 protease. The inflammasome containing the nucleotide binding domain-leucine-rich repeat (NBD-LRR) protein NLRC4 (interleukin-converting enzyme protease-activating factor [IPAF]) responds to the cytosolic presence of bacterial proteins such as flagellin or the ...
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ژورنال
عنوان ژورنال: Acta Crystallographica
سال: 2022
ISSN: ['2053-2733']
DOI: https://doi.org/10.1107/s2053273322097273